Low dose of aspirin is the main cause of gastro-duodenal ulcer. The best prevention is not definite particularly in patients without history of ulcer and infected by H. pylori.The aim of the study is to evaluate the gastric damage induced by aspirin in patients with H. pylori infection but who have any history of ulcer.
The aim of the study is to compare the protective effect of H. pylori eradication versus Pantoprazole versus placebo on the gastric damage induced by low dose of aspirin. Treatment are attributed by randomisation. Patients are followed for 6 months and gastric damage are evaluated by endoscopy at the end of this period.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
during one week for the active treatments placebo during 25 weeks
6 months at 20 mg
26 weeks, one tablet per day
Hotel Dieu Hospital
Paris, France
Measure: severity of the ulcerated gastric lesions induced by the aspirin
Time frame: 6 months
To measure: percentage of patients having had at least an ulcer
Time frame: 6 months
To measure: the average of the ranks of lesion in antrum and corpus.
Time frame: 6 months
To measure percentage of patients having had digestive clinical events
Time frame: 6 months
To measure: the average of the ranks of severity of the hemorrhagic lesions and erosive lesions evaluated in antrum and corpus by two analogical scales of 150 mm
Time frame: 6 months
To measure Percentage of patients having a hemorrhagic digestive of clinical expression or detected by the biological tests.
Time frame: 6 months
To measure : Elements of the histopathologic score of Sydney
Time frame: 6 months
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