Study Evaluating The SBI-087 In Subjects With Systemic Lupus Erythematosus

Inclusion Criteria: * Diagnosis of SLE (by greater than or equal to 4 American College of Rheumatology \[ACR\] Revised Criteria) greater than 6 months before study day 1. * History of a positive antinuclear antibody (ANA) titer greater than or equal to 1:160 or equivalent. Exclusion Criteria: * Treatment with more than 20 mg of prednisone per day. * Evidence of unstable clinically significant disease (e.g., cardiovascular, cerebrovascular, respiratory, or renal disease, or any other unstable serious disorder) other than SLE. * History of cancer (other than resected cutaneous basal and squamous cell carcinoma or in situ cervical cancer) with less than 5 years' documentation of a disease-free state.