Formulation and Food Effect Study of AZD1386 in Healthy Volunteers

Inclusion Criteria: * Females must be non-fertile (Amenorrhea and no pregnancy in the last 12 months prior to enrolment or documentation of being irreversible surgically sterile). * Healthy male volunteers with BMI between 18 and 30 kg/m2 * Clinical normal physical findings, including blood pressure, pulse rate above 45 bpm, ECG, and laboratory assessments. * Normal QTc interval on baseline ECG, between 360-450 msec, according to the Fridericia formula. Exclusion Criteria: * History of severe allergy/hypersensitivity or symptoms/signs of ongoing allergy/hypersensitivity as judged by the Investigator. * Requirement of concomitant medication during the study, excluding hormone replacement therapy (HRT) or use of drugs with enzyme inducing properties with 3 weeks of first dose * Smoking more than 7 cigarettes per week or consumption of more than 3 portion of snuff or equivalent per day within 30 days before first administration of study drug * A family history of short QT syndrome (SQTS) or sudden cardiac death (SCD) amongst first degree relatives and who have a QT/QTc \<360 ms