An Observational Study of Pruritus Amongst Hemodialysis Patients

Inclusion Criteria: * Patients aged ≥ 18 years; * Patients receiving chronic hemodialysis 3 or more times per week; * Patients who have "mild", "moderate" or "severe" pruritus; * "Mild" pruritus is defined as a nighttime or daytime worst itch intensity VAS \>10 mm and \< 40 mm at Screening and a combined daytime and nighttime Kawashima Itch Severity Score of \< 2; * "Moderate" pruritus is defined as a nighttime or daytime worst itch intensity VAS \>10 mm and \< 40 mm at Screening and a combined daytime and nighttime Kawashima Itch Severity Score of ≥ 3; * "Severe" pruritus is defined as a nighttime or daytime worst itch intensity VAS of ≥ 40 mm at Screening and a combined daytime and nighttime Kawashima Itch Severity Score of ≥ 3; * Patients who are able to understand and complete questionnaires written in English; * Patients who are expected to continue to dialyze at the present dialysis unit for the duration of the study. Exclusion Criteria: * Patients who have pruritus attributed to causes other than chronic kidney disease (CKD) or the direct consequences of CKD (i.e., hyperparathyroidism, circulating "uremic toxins"); * Patients who have had significant alteration in their dialysis regimen within the 2 weeks prior to Screening (or those for whom such changes are anticipated during the study) are excluded. A "significant alteration" is defined as: * A change in the type of hemodialysis filter; * An increase or decrease in total duration of dialysis prescribed of \> 1 hour/week; * A change in the site or type of venous access for dialysis; * An increase or decrease in prescribed blood flow of \>100 mL/min; * Patients who are unwilling to comply with the study protocol. Test Product, Dose, Mode of Administration and Duration of Treatment