Prospective Registry of Outcomes and Management of Acute Ischaemic Syndromes

Royal Brompton & Harefield NHS Foundation Trust1,340 enrolled

Overview

This is a multi-centre UK study designed to evaluate if an educational intervention programme delivered to health care professionals can improve the use of evidence based treatments in the management of patients admitted to hospital with non-ST elevation Acute Coronary Syndrome. A total of 38 centres participated, half received the educational intervention. Patients were followed to hospital discharge. Patients were followed up at 6 months. Longer term follow up through the Office Of National Statistics will be performed.

This is a multi-centre UK study designed to evaluate if an educational intervention programme delivered to health care professionals can improve the use of evidence based treatments in the management of patients admitted to hospital with non-ST elevation Acute Coronary Syndrome. A total of 38 centres participated. A cluster randomised method was used and half of centres received the educational intervention. Patients were followed to hospital discharge. Patients were followed up at 6 months and longer term follow up for mortality will be performed through the national databases.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

HEALTH_SERVICES_RESEARCH

Enrollment

1,340

Conditions

Acute Coronary Syndromes Coronary Artery Disease

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria:All patients admitted to the hospital (either through casualty or directly to the wards), with a good clinical history of an acute coronary syndrome with one or more of the following: 1. Ischaemic changes on the admission ECG (including patients with bundle branch block) 2. Elevated Troponin or cardiac enzymes on admission 3. Normal ECGs but with evidence of pre-existing coronary artery disease i.e., evidence of a prior history of MI, coronary revascularisation, coronary angiography demonstrating the presence of significant coronary stenosis or a stress test demonstrating ischaemia (treadmill, echo or nuclear scan) Written informed consent Exclusion Criteria: 1. Patients with persistent ST elevation \>1mm in two or more contiguous leads on the ECG. 2. Patients treated with thrombolytic therapy, or for whom thrombolytic therapy was considered on admission.

Locations (37)

University Hospital Aintree

Aintree, United Kingdom

Monklands Hospital

Airdrie, United Kingdom

Antrim Hospital

Antrim, United Kingdom

Barnet General Hospital

Barnet, United Kingdom

Barnsley District General Hospital

Barnsley, United Kingdom

Basildon Hospital

Outcomes

Primary Outcomes

Adherence to the educational programme measured by the frequency of use of the evidence based treatments: Aspirin, Heparin, Clopidogrel, Beta blockers, Statins.

Secondary Outcomes

Comparison of investigations and tests

Use of other treatments

Counselling for lifestyle changes

Referral to smoking cessation clinics

Cardiac rehabilitation

Compliance to treatment at 6 months

Comparison of clinical events at 6 months