The study is being done to investigate what happens to sildenafil in the body and how long it takes to get rid of this drug. Understanding how long the drug stays in the body and how it is changed by the body will help doctors determine the best dose. We also want to learn how well the medicine works based on the size of the dose or amount in the bloodstream.
There is no data regarding sildenafil drug disposition in infants and children with pulmonary hypertension. Sildenafil is used at The Children's Hospital of Philadelphia for the treatment of pulmonary hypertension. Patients receiving sildenafil as standard of care will be approached for consent.
Study Type
OBSERVATIONAL
Enrollment
9
Obtain blood samples at multiple timepoints.
The Children's Hospital of Philadelphia
Philadelphia, Pennsylvania, United States
To define the PK of sildenafil administered as standard of care in infants with pulmonary hypertension
Time frame: predose, .5mins after dose, 2-4 hrs after dose, and 5-7 hrs after dose
To describe the PD effects of sildenafil administered as standard of care in infants and children with pulmonary hypertension.
Time frame: Multiple time points throughout the study
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