A Specialized Diet for the Unique Metabolic Characteristics of Peripubertal African American Girls

University of Alabama at Birmingham30 enrolled

Overview

A diet (42% carbohydrate) specialized to the unique metabolic characteristics of peripubertal African AMerican girls (hyperinsulinemic, low insulin sensitive) will be more effective in maintaining glucose and insulin homeostasis compared to a standard diet (55% carbohydrate)

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

SINGLE

Enrollment

Conditions

Obesity Type 2 Diabetes

Interventions

DietaryOTHER

modification of macronutrient content

Eligibility

Sex: FEMALEMin age: 9 YearsMax age: 15 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * African American girls aged 9-14, * Overweight \< 90th percentile Exclusion Criteria: * On medications known to affect metabolism prior disease diagnosis

Locations (1)

University of Alabama at Birmingham

Birmingham, Alabama, United States

Outcomes

Primary Outcomes

decreased insulin secretion

Time frame: 25 weeks

Secondary Outcomes

decreased markers of inflammation; decreased estradiol concentration

Time frame: 25 weeks

Data from ClinicalTrials.gov

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