A Study to Assess the Safety and Efficacy of Prograf and MR4 in Kidney Transplantation Patients

Inclusion Criteria: * Patient must receive first oral dose of randomized study drug 2days(min 1day) prior to transplant procedure * Female patients of child bearing potential must have a negative urine or serum pregnancy test within 7 days prior to enrollment Exclusion Criteria: * Patient has previously received an organ transplant other than a kidney * Patient has received a Kidney transplant from non-heart beating donor or a cadaveric donor * Patients has received an ABO incompatible donor kidney * Recipient or donor is known to be seropositive for human immunodeficiency virus(HIV) * Patient has a current malignancy or a history of malignancy (within the past 5 years), except non-metastatic basal or squamous cell carcinoma of the skin that has been treated successfully * Patient has significant liver, disease, defined as having during the past 28 days continuously elevated AST (SGOT) and/or ALT (SGPT) levels greater than 3 times the upper value of the normal range of the investigational site * Patient has an uncontrolled concomitant infection(including Hepatitis B, Hepatitis C)or any other unstable medical condition that could interfere with the study objectives * Patient is currently taking or has been taking an immunosuppressive agents in the 30 days prior to transplant(except from two days prior to transplant) * Patient has a known hypersensitivity to tacrolimus * Patient is pregnant or lactating