Effects of Fatty and Lean Fish Intake on Cardiovascular Risk Factors in Subjects With Coronary Heart Disease

N/ACompletedNCT00720655

University of Eastern Finland33 enrolled

Overview

The aim of the study is to examine the effects of fatty fish and white (lean) fish on cardiovascular disease risk factor levels in subjects with established coronary heart disease using multiple medications. The main end points are blood pressure, serum lipids, inflammatory markers, arrhythmias and gene expression in peripheral mononuclear cells. The study design was a controlled, parallel study lasting 8 weeks with three diet groups: fatty fish, white fish and control group (lean pork, beef or chicken).

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Blood Pressure Arrhythmia Inflammation

Interventions

Eligibility

Sex: ALLMax age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: * myocardial infarction or unstable ischemic attack * use of beta blockers * normal sinus rhythm * fasting serum triglyceride less or equal to 3.5 mmol/l * fasting serum cholesterol less or equal to 8 mmol/l * BMI 18.5-30 kg/m2 * fasting plasma glucose less or equal to 7 mmol/l Exclusion Criteria: * diabetes * use of other antiarrhythmic medications than beta blockers * atrial fibrillation * use of psychotropic medications * abnormal liver, thyroid or kidney function * inflammatory bowel disease * excessive use of alcohol * use of fish oil supplements or high habitual intake of fish

Outcomes

Primary Outcomes

gene expression in peripheral mononuclear blood cells, risk of arrhythmias, serum lipids and blood pressure

Time frame: 8 week

Secondary Outcomes

inflammatory markers