The use of sugar and starch-like foods for energy (carbohydrate metabolism) changes when people sleep. However, it is still not known if differences in the amount of nighttime sleep have an effect on the carbohydrate metabolism of people who have a relative with type 2 diabetes (parent, sibling, or grandparent). This study is being done to test the hypothesis that individual differences in habitual sleep duration may be related to differences in the carbohydrate metabolism of people who have a history of type 2 diabetes in their family.
On two consecutive inpatient days, the participants in this study will undergo two different tests. The first test will determine how much insulin can their body produce in response to an intravenous glucose infusion over a period of several hours. The second test will determine how effective is the action of the sugar-processing hormone, insulin, in their body when it is infused intravenously together with glucose over a period of several hours.
Study Type
OBSERVATIONAL
Enrollment
20
University of Chicago
Chicago, Illinois, United States
Total body insulin sensitivity
Time frame: at the end of a 4-hour hyperinsulinemic clamp
First and second phase insulin secretion
Time frame: during a 3-hour hyperglycemic clamp
Endogenous glucose production
Time frame: before and during a 4-hour hyperinsulinemic clamp
Glycerol turnover and free fatty acid concentration
Time frame: before and during a 4-hour hyperinsulinemic clamp
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