Disulfiram Combined With Lorazepam for Alcohol Dependence and Anxiety Disorder

Inclusion Criteria: * Males and females age 18 and over with alcohol dependence. * Able to provide voluntary informed consent. * At least 4 heavy drinking days in the past 30 days. * Primary or secondary anxiety disorder, including diagnoses of generalized anxiety disorder, panic disorder, social phobia, PTSD, obsessive-compulsive disorder, alcohol-induced anxiety disorder, or anxiety disorder not otherwise specified, ascertained by the SCID. * Goal of abstinence. * 2 days abstinence at the time of study entry (did not drink yesterday or today). * Willing to come to clinic 3x/week. * If female of child-bearing potential, willing to use approved method of contraception. Exclusion Criteria: * Moderate or severe withdrawal (CIWA-A greater than 15), history of withdrawal seizures or delirium tremens. * Medical conditions (seizure disorder, sleep apnea, significantly impaired liver function, chronic or acute nephritis, symptomatic coronary artery disease, acute narrow-angle glaucoma). * Urine drug screen positive for opioids or barbiturates. * Hypersensitivity to thiuram derivatives. * Pregnancy. * Laboratory abnormalities (any LFT greater than 3 times normal, ECG evidence of ischemia, UA suggestive of nephritis, serious abnormalities of CBC). * Need to take excluded medication (e.g. amprenavir oral solution, diazoxide oral suspension, isoniazid, lopinavir/ritonavir oral solution, metronidazole, omeprazole, phenytoins, ritonavir, tinidazole, tipranavir, warfarin, azelastine, sodium oxybate). * Psychiatric conditions (schizophrenia, schizoaffective disorder, bipolar disorder; opioid dependence, benzodiazepine or other sedative hypnotic dependence).