Exploratory Study of OMS302 Injection in Subjects Undergoing Unilateral Cataract Extraction by Phacoemulsification.

Inclusion Criteria: * Subject is 50 years of age or older. * Subject is to undergo unilateral primary CELR for an age-related cataract under topical anesthesia and using a clear cornea incision. * Subject's history and physical examination are within normal limits or the examination is clinically non-significant for purposes of the study as determined by the Investigator, and subject is in good general health. * Subject has best corrected visual acuity (BCVA) of 20/400 or better in the non-study eye. * Subject has intraocular pressure (IOP) between 5 mmHg and 22 mmHg, inclusive, in the study eye. Exclusion Criteria: * Subject is allergic to any of the individual ingredients in OMS302 * Subject who is taking medications with the same activities as that of the active ingredients in OMS302 for defined time intervals prior to and after surgery. * Female subject of childbearing potential (i.e., not surgically sterilized nor post-menopausal longer than one year) who is not using an effective method of birth control within at least 14 days prior to surgery or has a positive pregnancy test. * Subject who has a present condition or history of any clinically significant uncontrolled gastrointestinal, cardiovascular, hepatic, renal, hematological, endocrine, neurological, psychiatric, connective tissue, respiratory, or medical disorder as determined by the Investigator. * Subject who is taking anticoagulants. * Subject who is taking or needs to take for the duration of the study any of the prohibited medications. * Subject with pseudo-capsular exfoliation, or evidence of prior iritis or of ocular trauma with iris damage, or who has used pilocarpine within six months of screening. * Subject that has uncontrolled chronic ocular disease. * Subject that has active corneal pathology or scarring noted in either eye (except superficial punctate keratopathy in the non-study eye). * Subject that has extraocular/intraocular inflammation in either eye. * Subject has an active bacterial and/or viral infection in either eye. * Subject that has narrow-angle glaucoma, unstable glaucoma, or glaucoma being treated with prostaglandins or prostaglandin analogues. * Subject taking, or has taken within the past year, an alpha adrenergic antagonist. * Subject that has participated in or is currently participating in any investigational drug or device trial within the previous 30 days prior to the day of surgery. * Subject that has had intraocular conventional surgery within the past three months or intraocular laser surgery within one month of the planned surgery in the study eye. * Subject that requires the use of other topical medications during the trial except prophylactic antibiotics, topical lid care or glaucoma medications or tear replacement solutions. * Subject that needs other ocular surgery at the time of the cataract extraction.