Fibrin Glue for Perianal Fistulas in Crohn's Disease: a Randomized Controlled Trial

Inclusion Criteria: * at least 18 years old * CD confirmed by endoscopy and histology. * CDAI should be 250 or less * at least one perianal fistula (between anus or low rectum and perineum, vulva or vagina) draining for more than 2 months duration Exclusion Criteria: * treatment with an anti-TNF agent or with ciclosporin or tacrolimus within the last 3 months * presence of a perianal abscess (\>1cm) assessed by magnetic resonance imaging (MRI) or endo-anal ultrasonography performed within the last month, * presence of anal or rectal stenosis, * surgery during the previous month (except seton removal), * previous fibrin glue injection, * pregnancy.