The Role of Dendritic Cells in Hepatitis C Infection

University College, London

Overview

The role of the dendritic cells, the most potent antigen presenting cells, in the establishment of chronic hepatitis C is not established. The study aims to define whether the dendritic cells are affected by the hepatitis C virus and whether that bears an impact on the antiviral immune response they generate. The hypothesis is explored by investigating a group of patients prior to and after the initiation of standard treatment for hepatitis C with pegylated Interferon and Ribavirin.

Study Type

INTERVENTIONAL

Purpose

BASIC_SCIENCE

Conditions

Chronic Hepatitis C Infection

Interventions

Viraferon-peg and RebetolDRUG

Eligibility

Sex: ALLMin age: 18 YearsMax age: 70 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * anti-HCV positive * HCV RNA positive Exclusion Criteria: * contraindications for antiviral treatment * concurrent chronic viral infections

Locations (1)

University College Hospital

London, United Kingdom

Outcomes

Primary Outcomes

Basic science research (immunology of hepatitis C)in hepatitis c patients receiving established, standard antiviral treatment (pegylated Interferon+Ribavirin)

Data from ClinicalTrials.gov

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