Evaluation of Therapeutic Effect of 0.5 mg Colchicine and 5 mg Prednisolone on Oral Aphthae

Mashhad University of Medical Sciences30 enrolled

Overview

The purpose of this study is to determine whether low doses of prednisolone, or colchicine are effective in the treatment of oral aphthae.

Treatment of recurrent aphthous stomatitis (RAS) remains, to date, empirical and non-specific. The main goals of therapy are to minimize pain and functional disabilities as well as decrease inflammatory reactions and frequency of recurrences.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Oral Aphthae

Interventions

PrednisoloneDRUG

5MG Prednisolone per day for 3 months

ColchicineDRUG

0.5 MG Colchicine per day for 3 months

Eligibility

Sex: ALLMin age: 15 YearsMax age: 60 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Confirmation of clinical diagnosis of aphthae * Having the experience of oral aphthae at least once in a month * Two weeks wash out periods after the last treatment Exclusion Criteria: * History of any systemic disease * Using drugs which affect immune system * Pregnancy and breast feeding * Aphthous related syndromes

Locations (1)

Mashhad Dental school

Mashhad, Khorasan Razavi, Iran

Outcomes

Primary Outcomes

frequency of ulcers

Time frame: 1 year

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.