Immune Response to Yellow Fever Vaccination in Adults With Atopic Dermatitis

Inclusion Criteria: * Diagnosis of Atopic Dermatitis or Non-atopic control * Born and currently residing in the United States * Weight of at least 110 lbs at the Screening Visit * Not previously vaccinated for YFV, tick-borne encephalitis (TBEV), Japanese encephalitis virus (JEV), or dengue fever * Agree to use adequate contraception 30 days prior to and until their participation in the study is completed. More information on this criterion can be found in the protocol. Exclusion Criteria: * AD subjects with exfoliative erythroderma or lacking a minimum 10 cm diameter area of normal appearing skin on the deltoid or thigh vaccination sites * Have a body mass index (BMI) of 30 or greater at the Screening Visit * Known history of infection with YFV, dengue fever, TBEV, JEV, or West Nile Virus (WNV) * A family history of severe reactions to the yellow fever vaccine * Traveled to Africa or South America (including participants who plan to travel to these areas prior to completion of the study) * History of egg allergy or have a positive egg allergy skin prick test that is administered at the Screening visit * History of acute hypersensitivity reaction to any components of the yellow fever vaccine (including gelatin) * Have latex allergy * Have lidocaine allergy * Are allergic or hypersensitive to TegadermTM * Received systemic immunosuppressants within 30 days prior to receiving the vaccination * Received systemic corticosteroids, anti inflammatory biologics (e.g., alefacept, etanercept, etc.), or calcineurin inhibitors within 30 days prior to receiving the vaccination * Received systemic antibiotics or antivirals within 7 days of receiving the vaccination * Received greater than 440 mcg of inhaled steroids per day within 6 months prior to receiving the vaccination * Received Xolair (Omalizumab) within 1 year prior to receiving the vaccination * Received immunotherapy within 30 days prior to receiving the vaccination * Received any vaccine within 30 days prior to randomization or expected receipt 30 days after randomization * Received topical antibiotics, antivirals, immune enhancers (e.g., imiquimod), or calcineurin inhibitors within 7 days prior to receiving the vaccination * Received topical corticosteroids within 7 days prior to receiving the vaccination * Received phototherapy (e.g., ultraviolet light B \[UVB\], psoralen plus ultraviolet light A \[PUVA\]) within 30 days prior to receiving the vaccination * Acute febrile illness or active fungal, bacterial, or viral infections (subjects may be reconsidered for enrollment once the condition has resolved) * Skin disease other than AD that might compromise the stratum corneum barrier (e.g., clinically evident ichthyosis, bullous disease, psoriasis) * Current or past history of malignancy or of autoimmune or immunodeficiency diseases. More information on this criterion can be found in the protocol. * Pregnant or breastfeeding * Have an anti-nuclear antibody (ANA) titer that is equal to or greater than 1/160 at the Screening Visit * Have a serum immunoglobulin (Ig)G, IgM, IgA, C3, or C4 level below the normal range at the Screening Visit * Have a manual lymphocyte count that is less than 1000 lymphocytes per microliter