Effect of Lowering the Dialysate Sodium on Blood Pressure in Hemodialysis Patients

London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's35 enrolled

Overview

Patients currently receiving hemodialysis will be randomized to receive 1 of 3 dialysate sodium prescriptions. The effects on blood pressure, interdialytic weight gain, thirst, and intradialytic symptoms will be assessed.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Enrollment

Conditions

Hemodialysis

Interventions

Lowering the dialysate sodiumOTHER

Please see above

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * patients on 3 times weekly hemodialysis of at least 3 months * elevated average ambulatory blood pressures * current dialysate sodium prescription 140mEq/L * average pre-dialysis serum sodium \<140mEq/L Exclusion Criteria: * frequent intradialytic hypotension * estimated life expectancy \<1 year * non-adherence to dialysis prescription * pregnancy * inability or unwillingness to complete study measures

Locations (1)

London Health Sciences Center

London, Ontario, Canada

Outcomes

Primary Outcomes

Ambulatory blood pressure

Ambulatory blood pressure to be taken over 24 hours at 4 week intervals throughout the study

Time frame: 3 months

Secondary Outcomes

thirst

Time frame: 3 months

QOL Scores (KDQOL, mins to recovery)

Time frame: 3 months

intradialytic hypotension rate, intradialytic symptoms

Time frame: 3 months

mechanistic outcomes: interdialytic weight gain, extracellular fluid water, sodium ionic mass balance

Time frame: 3 months

Data from ClinicalTrials.gov

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