Treatment of Acetaminophen Toxicity With N-acetylcysteine

Akron Children's Hospital130 enrolled

Overview

Retrospective chart review of patients who received N-acetylcysteine for APAP toxicity to assess length of oral vs IV treatment and overall healthcare costs.

Study Type

OBSERVATIONAL

Enrollment

130

Conditions

Acetaminophen Toxicity

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: * Admitted to CHMCA between June 1, 2004 to May 31, 2008 with a qualifying ICD-9 diagnosis code for the following APAP overdose situations; poisoning, accidental, suicide attempt, therapeutic use, assault, and undetermined (965.4, E850.4, E950.0, E935.4, E962.0, E980.0) * Serum APAP concentrations ≥ 150 g/mL at 4 hours or a serum concentration above the possible hepatotoxic line on the Rumack-Matthew's nomogram if obtained \> 4 hours post ingestion * Between the ages of 0-21 years Exclusion Criteria: * Serum APAP concentrations are not actually documented * Patient did not receive oral or IV NAC treatment * Patient has a preexisting liver disease such as cirrhosis or hepatitis C * Patient \> 21 years of age

Locations (1)

Children's Hospital Medical Center of Akron

Akron, Ohio, United States

Outcomes

Primary Outcomes

Duration of oral vs IV NAC treatment in hours

Time frame: From admission to discharge

Secondary Outcomes

Overall healthcare costs associated with IV vs Oral NAC treatment

Time frame: From admission to discharge

Data from ClinicalTrials.gov

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