This is a multi-centre prospective randomized controlled trial to explore the influence of ischemia-reperfusion injuries elicited by pringle manoeuvre during radical excision on the prognosis of Hepatocellular Carcinoma (HCC) patients.
Until now there are two popular procedures during the radical excision of primary liver cancer in our country.One is to give a pringle manoeuvre to control the operative blood loss,the other is using a combination of CUSA and Tissue-link to control the bleeding while without liver ischemia.According to the recent experimental studies in rats,we know that the ischemia and reperfusion injury may contribute to the metastasis of the tumor.In order to test the actual contribution of ischemia on human,we conduct this prospective clinical trial to compare the two popular procedures' effect on the prognosis of liver cancer patients undergoing radical excision.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
498
Radical excision of liver cancer without the procedure of pringle manoeuvre
curative resection liver cancer under pringle manoeuvre
Institute of hepatobiliary surgery,southwest hospital
Chongqing, Chongqing Municipality, China
Disease free survival
Time frame: 1,3,5-year
overall survival,morbidity,postoperative mortality;blood loss,Liver function test,etc
Time frame: baseline~2 weeks, 5-year overall survival
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