Admixture Mapping of Ethnic and Racial Insulin Complex Outcomes

University of Alabama at Birmingham360 enrolled

Overview

The main objective of this study is to investigate the effect of genetic and environmental parameters on racial/ethnic differences in aspects of insulin secretion and action. The genetic component will be modeled by estimating the degree of European genetic admixture (ADM) obtained from approximately 50 ancestry informative markers (AIMs). The environmental components will be modeled by measuring energy intake (food intake), energy expenditure (physical activity) and socioeconomic status.

Study Type

OBSERVATIONAL

Enrollment

360

Conditions

Healthy

Eligibility

Sex: ALLMin age: 7 YearsMax age: 12 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * African American, European American, or Hispanic American, aged 7-12, healthy, weight is equal to or greater than 25 Kg Exclusion Criteria: * Type 1 or 2 diabetes, polycystic ovary disease, disturbances in glucose or lipid metabolism disturbances * Use of medication known to affect body composition or physical activity, diagnosis of genetic disorders known to affect body composition or fat distribution * Use of tobacco, alcohol consumption in excess of 400 g per week * Menstruated for more than a year prior to the recruitment; OR * A medical history that counter-indicates inclusion of the study

Locations (1)

University of Alabama at Birmingham

Birmingham, Alabama, United States

Outcomes

Primary Outcomes

To test the role of European genetic admixture on measures of insulin action and response in a multiethnic group of prepubertal children.

Time frame: 5 years

To investigate whether the impact of energy intake, energy expenditure and socioeconomic status on proxy measures of insulin sensitivity and/or action differ as a function of European ADM in prepubertal children

Time frame: 5 years

To test phenotype-genotype associations between each one of the AIMs and measures of FI, SI and AIRg after adjusting for body composition in a sample of AA, HA and EA prepubertal children.

Time frame: 5 years

Data from ClinicalTrials.gov

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