The Effects of Butyrate Enemas on Visceral Perception

Maastricht University Medical Center11 enrolled

Overview

During this double blind, placebo controlled, randomised cross over study, healthy volunteers received an enema once daily for one week containing either placebo (saline), 50mM butyrate or 100mM of butyrate. Before and directly after each test period a barostat protocol was performed to measure parameters for visceral perception.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

QUADRUPLE

Enrollment

Conditions

Visceral (Hyper)Sensitivity

Interventions

ButyrateDRUG

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * healthy Exclusion Criteria: * age, under 18 or over 65 * use of pre- or probiotics during study and 3 months previous to study * previous bowel complaints * gastrointestinal disease or abdominal surgery

Locations (1)

Maastricht University

Maastricht, Limburg, Netherlands

Data from ClinicalTrials.gov

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