Genetic Analysis of Children With Cyclic Vomiting Syndrome (CVS) and Migraines

Medical College of Wisconsin586 enrolled

Overview

The purpose of this study is to determine if there are genetic variations that can explain a genetic basis for cyclic vomiting syndrome (CVS).

The purpose of this study is to determine if there are genetic variations that can explain a genetic basis for cyclic vomiting syndrome (CVS), various phenotypes of CVS (e.g. menstrual, Sato, calendar-tied) and migraine headaches (e.g. with aura, without aura, hemiplegic migraine). This information will allow physicians to improve care for patients who have been diagnosed with this disease and to provide their parents with more complete information regarding the cause of this disease. This research is being done because many unanswered questions remain regarding children with CVS.

Study Type

OBSERVATIONAL

Enrollment

586

Conditions

Vomiting Migraines

Eligibility

Sex: ALLMax age: 21 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Subjects age 0-21 years old with CVS (different phenotypes). Each patient's authorized legal guardian must understand the nature of the study and must provide written informed consent. Exclusion Criteria: * Subjects age \> 22 years old Vomiting is not due to CVS or other related condition

Locations (1)

Children's Hospital of Wisconsin

Milwaukee, Wisconsin, United States

Outcomes

Primary Outcomes

Identify novel genes that contribute to the risk of CVS using genomewide association analysis approach.

Time frame: 3 years

Secondary Outcomes

Perform genotype-phenotype correlations between genetic profiles and various phenotypes of CVS (e.g. menstrual, Sato, calendar-tied) and migraine headaches (e.g. with aura, without aura, hemiplegic migraine)

Time frame: 3 years

Data from ClinicalTrials.gov

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