The Use of L-Carnitine And CoQ10 Supplements In the Treatment of Cyclic Vomiting Syndrome (CVS)

Medical College of Wisconsin

Overview

This is a study with the principle goal being to learn about the use of L-Carnitine and CoQ10, two vitamin supplements that are currently being used to treat Cyclic Vomiting Syndrome, largely initiated by parents. We want to learn how effective these supplements are compared to standard treatment, at what dose, and what onset of action in order to initiate future prospective study on these supplements.

Study Type

OBSERVATIONAL

Conditions

Cyclic Vomiting Syndrome

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: * 3 discrete episodes of vomiting * normal health between episodes * stereotypical clinical pattern * no abnormal test results to account for vomiting (see exclusion criteria) Exclusion Criteria: * abnormal UGI with small bowel follow-through revealing an anatomic anomaly, inflammatory or obstructive * Significantly abnormal endoscopic biopsies (moderate to severe esophagitis, H. pylori) * Abnormal abdominal ultrasound revealing hydronephrosis, cholelithiasis, pancreatitis * Positive screening for endocrine disorder (diabetic ketoacidosis, Addison's) * Positive screening for inborn errors of metabolism (hypoglycemia, lactic acidosis, hyperammonemia, organic acidemia, amino aciduria, elevated beta-ALA, porphobilinogen)

Locations (1)

Children's Hospital of Wisconsin

Milwaukee, Wisconsin, United States

Outcomes

Primary Outcomes

How two vitamin supplements are being used to treat cyclic vomiting syndrome

Time frame: Two years

Secondary Outcomes

How effective these supplements appear to be compared to standard treatment

Time frame: Two years

Data from ClinicalTrials.gov

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