1. To determine if catheter-based atrial fibrillation (AF) ablation is superior to Amiodarone treatment for symptomatic persistent/permanent AF in ICD/CRTD patients with an impaired left ventricular function. 2. Hypothesis: AF ablation is better than Amiodarone for subjects with symptomatic persistent or permanent AF and impaired LV function in terms of recurrence of AF, quality of life, 6-minute walk distance, EF and total number of hospitalizations.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
203
Radio-frequency catheter ablation of atrial fibrillation
Taken orally on a daily basis.
Texas Cardiac Arrhythmia Research Foundation
Austin, Texas, United States
Time to Recurrence of AF lasting longer than 15 seconds
Time frame: 1 year
Change in distance walked in 6-minute walk test
Time frame: 1 year
Total number of hospitalizations during the trial period for each group
Time frame: 1 year
Change in MLHF Quality of Life during trial period
Time frame: 1 year
Change in EF during trial period
Time frame: 1 year
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