Clonidine-Remifentanil. Effect of the Combination on Acute Pain and Respiration in Healthy Volunteers

Oslo University Hospital12 enrolled

Overview

The hypothesis is that systemic remifentanil and Clonidine act in a synergistic manner to relief acute main in an experimental human pain model. Of interest is also the effect of the combination on respiration, sedation and cognitive behavior.

To examine the possible synergistic effects og systemic remifentanil and clonidine. Its effects on respiration, cognitive function and sedation.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

TRIPLE

Enrollment

Conditions

Acute Pain Respiration Sedation

Interventions

Remifentanil+clonidineDRUG

iv Remifentanil+ iv clonidine

Eligibility

Sex: ALLMin age: 18 YearsMax age: 50 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Healthy volunteers Exclusion Criteria: \-

Locations (1)

Dep of Anesthesia and Intensive Care, Rikshospitalet-Radiumhospitalet Medical Center

Oslo, Norway

Outcomes

Primary Outcomes

Relief of pain(VAS reduction)

Time frame: Experimental

Secondary Outcomes

Reduction in Minute ventilation

Time frame: Experimental

Reduction in CO2 stimulated Minute Ventilation

Time frame: experimental

Reduction in BIS score

Time frame: Experimental

Performance on Stroop test

Time frame: Experimental

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.