Quality Assurance of Administering Methylphenidate in Adults With Attention Deficit Hyperactivity Disorder (ADHD) - QUMEA

Inclusion Criteria: * patient treated as out-patient * score of 85 or greater in IQ-test (MWT-B) * diagnosis of ADHD according ADHS-CL (DSM IV) and WRAADDS \> 35 points * ADHD symptoms have existed since childhood (WURS-k \>= 30) * Body Mass Index \>= 20 and body weight \< 130 kg * willing to eat breakfast and lunch * patient is willing and able to come to the observation appointments * written consent of the patient to participate in the study Exclusion Criteria: * treatment with psychostimulants in the past two weeks before screening * shift work or night work * alcohol, medication or drug dependency in the past six months or manifest drug abuse * diagnosis of a psychosis (SKID-I) * epileptic attacks in the past * EEG result which suggests epilepsy * acute depressive episode according to ICD-10 F32.2 and ICD-10 F32.3 (Beck-Depression-Inventory \> 18) * Illness with schizophrenic symptoms (SKID-I) * acute manic episode, bipolar disorder(SKID-I) * diagnosis of a tic disorder * acute anorexia * acute prominent panic disorder and generalised anxiety (SKID-I) * clinically relevant kidney disorders * creatinine \> 1,5 x upper norm-range * clinically relevant liver disorder * SGOT and/or SGPT \> 2 x upper norm-range * pathological ECG-finding * QTc \> 450 msec in male, QTc \> 470 msec in female * high blood pressure (anamnesis or blood pressure \> 140/90 mm Hg at screening) * known acclusive arterial disease * angina pectoris (anamnesis or ECG-finding) * cardiac arrhythmias (anamnesis or ECG-finding) * KHK (anamnesis or ECG-finding) * post heart-attack status (anamnesis or ECG-finding) * post stroke status * known elevated intra-ocular pressure * known enlarged prostates * latent and manifest hyperthyreosis * TSH \< lower norm-range * patient with a terminal disease (e.g. cancer) * participation in a clinical study within the past 30 days * participation in this study at an earlier point in time * simultaneous participation in another clinical trial * women of child-bearing age without adequate contraception (contraceptives, intrauterine device , no sexual intercourse) * pregnancy (positive pregnancy test) or lactation period