Fatty Liver and Obstructive Sleep Apnea

Assaf-Harofeh Medical Center

Overview

Non-alcoholic fatty liver disease is associated with obstructive sleep apnea. Abnormalities in liver enzymes can improve following continuous positive airway pressure in patients with obstructive sleep apnea. Computerized tomography can be used to quantify fatty liver changes. We hypothesize that continuous positive airway pressure can reduce morphologic fatty liver changes in patients with obstructive sleep apnea and non-alcoholic fatty liver, an that this reduction can be evident using computerized tomography

Study Type

INTERVENTIONAL

Purpose

TREATMENT

Conditions

Non-Alcoholic Fatty Liver Disease Obstructive Sleep Apnea

Interventions

Continuous positive airway pressureDEVICE

Eligibility

Sex: ALLMin age: 30 YearsMax age: 60 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Obstructive sleep apnea, defined as AHI\>5/h Exclusion Criteria: * Consumption of more than 20 grams of alcohol per 24 h * Known autoimmune disease * Usage of known hepatotoxic drugs * Medical history positive for viral hepatitis or other chronic liver disease

Locations (1)

The pulmonary institute, Asaf Harofeh Medical Center

Ẕerifin, Israel

Outcomes

Primary Outcomes

Reduction in fatty liver changes on computerized tomography

Time frame: Within 1-2 years

Secondary Outcomes

Improved liver enzymes abnormalities

Time frame: Within 1-2 years

Data from ClinicalTrials.gov

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