This study examined the safety and effectiveness of long-term administration of mometasone nasal spray in patients with perennial allergic rhinitis. Patients received mometasone for 12 weeks plus an additional 12 weeks if patient agreed to continue. Dose of mometasone could be decreased or increased during the study based on patient's response.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
98
Two sprays mometasone nasal spray per nostril once daily (200 mcg/day). After 4 weeks, dose can be decreased to one spray per nostril daily or increased to 4 sprays per nostril daily.
Change from Baseline in 4 nasal symptom score.
Time frame: All visits starting 2 weeks prior to treatment until 5 to 9 days after last administration of treatment
Individual nasal symptom scores (sneezing, attack, rhinorrhea, nasal congestion, and nasal itching)
Time frame: All visits starting 2 weeks prior to treatment until 5 to 9 days after last administration of treatment
Overall improvement (combination of nasal symptoms and rhinoscopic nasal findings)
Time frame: All visits during which patient is receiving drug (includes the 12 week drug administration period plus the 12 week additional drug administration period)
Adverse events
Time frame: Throughout the study once initial treatment has started and until 5 to 9 days after last administration of treatment.
Laboratory tests
Time frame: At baseline, and 4, 12, and 24 weeks after treatment
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