Safety/Efficacy of Antibiotic Steroid Combination in Treatment of Blepharitis and/or Keratitis and/or Conjunctivitis

Federal University of São Paulo100 enrolled

Overview

Safety and efficacy of antibiotic steroid combination compared with individual administration in the treatment of bacterial ocular inflammation and infection (blepharitis and/or keratitis and/or conjunctivitis).

Antibiotic/steroid combination compared to individuals components 8 days of treatment.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

100

Conditions

Blepharitis Conjunctivitis Keratitis

Interventions

Moxifloxacin and Dexamethasone combinedDRUG

moxifloxacin 0,5% qid and dexamethasone 0,1% qid combined

MoxifloxacinDRUG

moxifloxacin 0,5% qid and

DexamethasoneDRUG

dexamethasone 0,1% qid

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients with diagnosis of blepharitis and/or keratitis and/or bacterial conjunctivitis Exclusion Criteria: * Uncontrolled glaucoma or intraocular hypertension * Wear contact lens during the study * Patients with sight in a single eye * Suspicious of viral, fungic infection * Use of any other ophthalmic drugs during the study * Use of immunosuppressant therapy * Known or suspected allergy or hypersensibility to any component of study medication

Locations (1)

Federal University of Sao Paulo

São Paulo, São Paulo, Brazil

Outcomes

Primary Outcomes

Evaluation of ocular sign/symptoms (hyperemia on bulbar conjunctiva, palpebral conjunctiva, conjunctival exsudates, palpebral erythema at final visit (Day 8)

Time frame: Day 8

Secondary Outcomes

Evaluation of sign and symptoms of blepharitis and/or keratitis and/or bacterial conjunctivitis

Time frame: Day 8

Data from ClinicalTrials.gov

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