Combination of Sulfonylureas and Insulin Glargine Outpatient Therapy for Unstable Diabetes and Impending DKA

Inclusion Criteria: * Individuals more than 18 years of age with DM2, either with new onset DM2 or known diabetics who did not take oral hypoglycemic agents for more than 2 weeks, presenting with fasting blood glucose (FBG) 300-500 mg/dl or random blood glucose (RBG) 400-700 mg/dl and who did not have any exclusion criteria listed in Table 1, were eligible for the study. Exclusion Criteria: * Acute metabolic complications (diabetic ketoacidosis, hyperosmolar hyperglycemia associated with dehydration). * Acute complications of chronic cardiovascular, neurological, renal, and other diabetic complications. * Any subject with unstable vitals signs (temperature \> 101 degrees F, systolic blood pressure \< 90 or \> 180 mm hg, diastolic blood pressure \< 60 or \> 110 mm hg, heart rate \< 60 or \> 120 beats/minute). * Electrolyte imbalances (serum bicarbonate level \< 20 mEq/L, serum sodium \< 125 \& \> 150 mEq/L, serum potassium \< 3.5 \& \> 5.5 mEq/L). * Evidence of an impaired sensorium and/or dementia. * Age \> 75 years * Subjects with any acute medical illness. * Type 1 diabetes or type 2 diabetics weighing less than 120 lbs * Current addiction to illicit substances or alcohol abuse * Pregnant or lactating subjects