Effects of Omega-3 Fatty Acids and Menaquinone-7 on Thrombotic Tendency

Maastricht University Medical Center57 enrolled

Overview

Omega-3 fatty acids are notably present in fish oil and krill oil, and are known to have beneficial effects on the vasculature. Vitamin K2 is known for preventing vascular calcification. In this study we investigate a potential synergy between the effects of either fish or krill oil and menaquinone-7, which is one of K2 vitamins.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

DOUBLE

Enrollment

Conditions

Atherosclerosis

Interventions

menaquinone-7DIETARY_SUPPLEMENT

capsule consisting of 10, 20 or 45 µg menaquinone-7 per day during 8 weeks

fish oilDIETARY_SUPPLEMENT

9 fish oil capsules equivalent to 3 gram per day of n-3 polyunsaturated fatty acids during 12 weeks

krill oilDIETARY_SUPPLEMENT

9 krill oil capsules, equivalent to 1,5 gram per day of n-3 polyunsaturated fatty acids (PUFA) during 12 weeks

Eligibility

Sex: ALLMin age: 25 YearsMax age: 50 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Healthy subjects - BMI \< 30 * written informed consent Exclusion Criteria: * Use of oral anticoagulants * Coagulation disorders * Use of multivitamin supplements * Use of corticosteroids, anticonceptives * hypertriglyceridemia, hypercholesterolemia

Locations (1)

VitaK - Maastricht University

Maastricht, Netherlands

Outcomes

Primary Outcomes

Endogenous Thrombin Potential (ETP)

Time frame: 12 weeks

Secondary Outcomes

Osteocalcin carboxylation

Time frame: 12 weeks

Matrix Gla-protein carboxylation

Time frame: 12 weeks

Data from ClinicalTrials.gov

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