Effect of Calcium on Tasigna Pharmacokinetics (PK) in Healthy Volunteers

Inclusion Criteria: * Healthy men or women 18 years of age or older. Healthy subjects are defined as individuals who are free from clinically significant illness or disease (such as coronary arterial disease, chronic heart failure, bleeding disorder, hypertension, chronic renal failure etc.) as determined by their medical history, physical examination, and laboratory studies. * Body Mass Index (BMI) \< 31 kg/m2 (weight/height2). * Female patients of childbearing potential must have negative pregnancy test within 14 days before initiation of study drug dosing. Postmenopausal women must be amenorrheic for at least 12 months to be considered of non-childbearing potential. Male and female patients of reproductive potential must agree to employ an effective barrier method of birth control throughout the study and for up to 3 months following discontinuation of study drug. * Written, voluntary informed consent. Exclusion Criteria: * Abnormal marrow function as defined by leucocyte, neutrophil, or platelet counts outside of normal limits. * Any evidence of renal dysfunction (proteinuria; serum creatinine \> upper limit of normal; or if serum creatinine \> upper limit of normal, a calculated creatinine clearance \< 60 mL/min/1.73 m2). * Impaired hepatic function (liver enzymes greater than the upper limit of normal or bilirubin outside the normal range). * QTcF \> 450 msec on screening ECG (using the QTcF formula). * Patient with electrolyte abnormality (e.g., hypokalemia, hypomagnesemia, hypophosphatemia, hyperkalemia, hypocalcemia, hyponatremia). * Taking any medications (including over the counter products), herbal products, mineral supplements or vitamins (other than a daily multivitamin preparation), other than contraceptives (for women), within 2 weeks of start of the study. All forms of contraceptive medication are permissible for this study and would not result in a female's exclusion from participation. Patients who take medications on a chronic basis, such as antihypertensive medications or thyroid replacement therapy, etc. are not eligible for the study. * Subjects has received any other investigational agents within 28 days of first day of study drug dosing. * Female subjects who are pregnant or breast-feeding.