Single Dose Escalation Study of PF-04360365 In Subjects With Mild To Moderate Alzheimer's Disease

Inclusion Criteria: * Male or female (of non-child bearing potential) subjects ages ≥50 years of age. * Diagnosis of probable AD (of mild to moderate severity), consistent with criteria from both: NINCDS-Alzheimer's Disease and Related Disorders Association (ADRDA) and DSM-IV-TR. * MMSE score of 16-26 inclusive. * Rosen-Modified Hachinski Ischemia Score ≤4. * On a stable dose of background cholinesterase inhibitors or memantine for at least 60 days prior to dosing. Exclusion Criteria: * Diagnosis or history of other dementia or neurodegenerative disorders. * Diagnosis or history of clinically significant cerebrovascular disease. * Specific findings on magnetic resonance imaging (MRI); cortical infarct, micro hemorrhage, multiple white matter lacunes. * History of allergic or anaphylactic reactions.