The aim of the proposed research is to measure the effect of drug-induced sedation on the functional connectivity between brain regions as indicated by EEG signal transmission within the human brain. The results of this study will help to identify the neurophysiological correlates of changes in conscious experience that occur during drug-induced sedation.
In the proposed experiments cortical areas will be stimulated using low frequency, low-amplitude transcranial magnetic stimulation (TMS) in healthy human subjects during wakefulness and during drug-induced responsive sedation and unresponsive sedation. Simultaneously, high-density electroencephalography (Hd-EEG) will be recorded to evaluate the temporal and spatial characteristics of evoked responses and induced rhythms over the cortex.
Study Type
OBSERVATIONAL
Enrollment
20
University of Wisconsin Hospital and Clinics
Madison, Wisconsin, United States
Defining the neurophysiological conditions that are necessary for conscious experience.
Time frame: Immediate
Understanding the neurophysiological correlates of conditions associated with restricted conscious experience such as sedation and anesthesia.
Time frame: Immediate
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