Efficacy and Safety of a Cutaneous Formulation of Gonyautoxin 2/3 (GTX 2/3) for the Treatment of Facial Wrinkles

Inclusion Criteria: * Women with no bearing-child potential or with adequate birth control method. * Volunteers between 30 to 60 years of age. * Subjects with bilateral crow's feet wrinkles. * Regular user of cosmetic products, willing and able to comply with the study objectives. * Signed informed consent. Exclusion Criteria: * Any medical condition or any use of a medication that could modify the study results (e.g.: NSAIDs, immunosuppressant drugs, insulin...). * Any other significant medical condition (e.g.: diabetes mellitus, heart disease, liver disease...). * Any other condition that in the investigator's opinion could not be appropriate with the participation in this trial. * Any health condition that could affect the evaluation of study parameters. * Acute or chronic skin disease. * History of allergic reaction to cosmetic compounds. * Pregnancy, planned pregnancy or breast-feeding. * Allergy to shellfish, fish or sea product (seaweed). * Known or suspected hypersensitivity to any of the study product compounds. * Participation in another clinical trial within 30 days previous to enrolment. * Known or suspected alcohol or drug abuse.