Study to Evaluate the Efficacy, Safety, Tolerability and Immunogenicity of 100µg NIC002 Vaccine in Cigarette Smokers Who Are Motivated to Quit Smoking.

Inclusion Criteria: * Healthy male and female smoking subjects age 18 to 65 years of age * Subjects must be smoking 10 or more cigarettes per day during the past 12 months * The exhaled breath carbon monoxide (CO) concentration must be 10 ppm or more at screening. Urine cotinine at screening must be positive. * The Fagerström Test for Nicotine Dependence (FTND) score of 5 or above at screening. Exclusion Criteria: * Attempted to quit smoking in the three (3) months. * Prior use of smoking cessation aid. Other protocol-defined inclusion/exclusion criteria may apply