A Study to Evaluate Tenofovir Disoproxil Fumarate (DF) in Asian-American Adults With Chronic Hepatitis B Infection

Inclusion Criteria: * Male or female * Asian-American, defined as a person of self-reported Asian ancestry who is residing in the United States (US) * 18 through 75 years of age, inclusive * Documented chronic HBV infection, defined as positive serum HBsAg =/\> 6 months * HBV DNA =/\> 10,000 copies/mL (PCR method) * ALT \> ULN and \</= 10 × ULN at screening or within the past 12 months prior to screening * Willing and able to provide written informed consent * Negative serum beta-human chorionic gonadotropin (HCG) pregnancy test (females of child-bearing potential) * Estimated glomerular filtration rate (creatinine clearance) =/\> 60 mL/min/1.73m\^2 by the Cockcroft-Gault equation * Adequate hematologic function (absolute neutrophil count =/\> 1,500/mm\^3; hemoglobin =/\> 10.0 g/dL) * No prior TDF therapy; participants may have taken \< 12 weeks of oral anti-HBV therapy, with the last dose =/\> 16 weeks prior to screening; participants may have received prior interferon, but must have discontinued interferon therapy =/\> 6 months prior to screening Exclusion Criteria: Participants who meet any of the following exclusion criteria are not to be enrolled in this study. * Pregnant women, women who are breast feeding or who believe they may wish to become pregnant during the course of the study. * Males and females of reproductive potential who are not willing to use an effective method of contraception during the study. For males, condoms should be used and for females, a barrier contraception method should be used in combination with one other form of contraception. * Decompensated liver disease defined as direct (conjugated) bilirubin \> 1.2 X ULN, prothrombin time (PT) \> 1.2 X ULN, platelets \< 150,000/mm3, or serum albumin \< 3.5 g/dL * Prior history of clinical hepatic decompensation (eg, ascites, jaundice, encephalopathy) or variceal hemorrhage * Receipt of prior TDF treatment * Receipt of =/\> 12 weeks of oral anti-HBV nucleoside/nucleotide therapy, or receipt of ANY oral anti-HBV treatment \< 16 weeks prior to screening * Receipt of interferon (pegylated or not) therapy within 6 months of the Screening Visit * alpha-fetoprotein \> 50 ng/mL * Evidence of hepatocellular carcinoma (HCC) * Co-infection with human immunodeficiency virus (HIV), hepatitis C virus (HCV), or hepatitis D virus (HDV) * History of significant renal disease (eg, nephrotic syndrome, renal dysgenesis, polycystic kidney disease, congenital nephrosis, acute tubular necrosis, other renal disease) * History of significant bone disease (eg, osteomalacia, chronic osteomyelitis, osteogenesis imperfecta, osteochrondroses, multiple bone fractures) * Significant cardiovascular, pulmonary or neurological disease * Evidence of a gastrointestinal malabsorption syndrome that may interfere with absorption of orally administered medications * History of solid organ or bone marrow transplantation * Ongoing therapy with any of the following: nephrotoxic agents, competitors of renal excretion (eg, probenecid), systemic chemotherapeutic agents, systemic corticosteroids, Interleukin-2 (IL-2) and other immunomodulating agents, investigational agents (except with the expressed approval of the Sponsor); administration of any of the above medications must be discontinued at least 30 days prior to the Baseline Visit and for the duration of the study period * Known hypersensitivity to the study drugs, the metabolites, or formulation excipients * Any other condition (including alcohol or substance abuse) or prior therapy that, in the opinion of the Investigator, would make the participant unsuitable for the study or unable to comply with dosing requirements