Fast awakening from anesthesia is one of the major characteristics of remifentanil-associated anesthetic induction and maintenance, whereas corresponding pain during awakening influences patient's rehabilitation strongly. In addition, such early postoperative pain results in significant stress responses, which displays as further release of stress hormones such as cortisol and β-endorphin as well. How to prevent such acute pain resulting from remifentanil's fast metabolism endows clinical significance. This study is designed to compare the analgesic efficacy of fentanyl, sufentanil and butorphanol delivered after gynecological laparoscopic surgeries that underwent remifentanil induction and maintenance, and investigate corresponding influence on the levels of blood cortisol and β-endorphin.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
150
Fentanyl 0.5 μg/kg delivered intravenously immediate at the end of remifentanil pump finished
Sufentanil 0.05 μg/kg delivered intravenously immediate at the end of remifentanil pump finished
Butorphanol 0.01 mg/kg delivered intravenously immediate at the end of remifentanil pump finished
Nanjing Maternal and Child Health Care Hospital
Nanjing, Jiangsu, China
VAS ratings of pain
Time frame: 0 min after awake from anesthesia; 5,10,15,20 and 30min after awake from anesthesia
Hemodynamics of patients
Time frame: 30min before operation; every 10min during operation; 5,10,15,20,30 and 60min after operation
Sedative ratings with VAS system
Time frame: 0,5,10,15,25,45 and 60min after awake from anesthesia
Overall VAS satisfaction ratings
Time frame: 1 h after operation
Blood cortisol and β-endorphin levels
Time frame: 0, 10min before the end of surgeries, 10min, 1h and 6h after operation
Side effects
Time frame: 1 h after operation
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