Phase II Study to Evaluate the Effectiveness of EVT 302 in Smoking Cessation.

Inclusion Criteria: * Smoker of at least 10 cigarettes daily * Motivated to quit smoking * Reports at least one unsuccessful attempt to quit in the last 2 years * In generally good health * Provides written informed consent to participate in the sudy Exclusion Criteria: * Pregnant or nursing females. * Women of child-bearing potential must agree to use acceptable contraceptive precautions (contraceptive pill and one barrier method)during the study and for 2-months thereafter * History of anaphylaxis * History of alcohol or drug abuse * History of or current significant medical or psychiatric disorder * History or presence of cataract or abnormality identified by slit lamp investigation * Use of other MAO inhibitors, pethidine, SSRIs, tricyclic antidepressants,nasal or oral decongestants or cold medicines containing ephedrine, pseudoephedrine or other sympathomimetics. * Any medicine contraindicated for use with MAO inhibitors. * Have or be a carrier of hepatitis B or c or HIV 1 or 2 * Use of tobacco products other than cigarettes * Use of nicotine replacement therapy in the past month * Received an investigational drug in the past 30 days * Previous participation in a study with a MAO-B inhibitor