The aim of AUTAX study is to investigate the frequency of MACCE in patients with multivessel disease and multiple Taxus stent implantations in the "real world" stenting at 30 days, 6 and 12 months at 2 year follow-up. Because multivessel stenting using DES has been limited due to economic considerations, the secondary aim is to enhance experience in multivessel stenting with drug-eluting stents in order to improve short- and long-term outcomes of the patients with severe multiple coronary artery stenoses. The objectives of the study are: 1. To determine the frequency of MACCE at 30-day, 6 and 12-month and at 2 year clinical follow-up after multivessel intervention with drug-eluting stents in a prospective patient cohort.. 2. To determine the rate of in-stent restenosis, target lesion and target vessel revascularization (angiographic measures) 6 months in patients with multiple DESs in multiple lesions. 3. To investigate the clinical and angiographic outcomes after implantation of multiple DESs in the subgroup of patients with accompanying diseases (diabetes mellitus, renal insufficiency) with known high restenosis and late complication rate. 4. To evaluate potential cost burden in attempting a strategy of complete revascularization by multiple DES in patients with multivessel disease.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
441
Taxus stent implantation in patients with multivessel coronary artery disease
Landeskrankenhaus
Bruck an der Mur, Austria
Department of Interventional Cardiology, Academic Hospital
Feldkirch, Austria
Landeskrankenhaus Graz-West
Graz, Austria
Allgemeines Krankenhaus der Stadt Linz
Linz, Austria
Krankenhaus Barmherzigen Schwestern
Linz, Austria
St. Johannes Spital
Salzburg, Austria
Rudolfstiftung
Vienna, Austria
Incidence of MACCE, defined as all-cause death, nonfatal acute myocardial infarction (AMI) target vessel revascularization (TVR) and cerebrovascular event during the two-year clinical follow-up (FUP)
Time frame: 2 year
Break-down primary endpoints at the 2-year FUP, as the rate of TVR, non-fatal AMI, all-cause death, stroke and the composite of death and AMI
Time frame: 2 year
Incidence of 30-days, 6-mo and 1-year MACCE
Time frame: 1 year
Acute, subacute and late thrombosis rates
Time frame: 2 year
Angiographic end-points as the binary restenosis rate per lesion (defined as diameters stenosis ≥ 50%), in-stent and proximal and distal in-lesion late lumen loss
Time frame: 6-month
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.