Single Ascending Dose Study of the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of HSD-016

Inclusion: 1. Men or women of nonchildbearing potential aged 18 to 50 years inclusive at screening. 2. Healthy as determined by the investigator on the basis of screening evaluations. 3. Nonsmoker or smoker of fewer than 10 cigarettes per day as determined by history. Exclusion: 1. No presence or history of any disorder that may prevent the successful completion of the study. 2. No history of drug abuse within 1 year.