A Pilot Study to Evaluate the Systemic Inflammatory Response of Thoracoabdominal Aortic Aneurysm Repair.

The University of Texas Health Science Center, Houston

Overview

The purpose of this study is to look at the systemic inflammatory response caused when patients undergo thoracoabdominal aortic aneurysm repair (TAAA). In addition, this study will look at how the inflammatory response affects the post operative healing process and post operative complications.

Patients will be invited to participate in this study prior to the TAAA repair procedure. Prior to the surgery, baseline blood and saliva samples will be collected. Following the surgery, blood and saliva samples will be collected for 48 hours. In addition, hemodynamic data (i.e. vital signs) will be collected for the first 48 hours. The patient data will be reviewed for the first 30 days for morbidity and mortality assessment.

Study Type

OBSERVATIONAL

Conditions

Aortic Aneurysm, Thoracic Systemic Inflammatory Response Syndrome

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Elective TAAA repair Exclusion Criteria:

Outcomes

Primary Outcomes

to evaluate the effects of TAAAA repair on pro-inflammatory mediators and the anti-inflammatory mediators IL-1 receptor antagonist and IL-10.

Time frame: 30 days

Secondary Outcomes

To characterize the inflammatory response after TAAA repair and delineate any association to post-operative morbidity

Time frame: 30 days

Data from ClinicalTrials.gov

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