Use of Electroconvulsive Therapy (ECT) in Chronic, Severe, Treatment Resistant Posttraumatic Stress Disorder

Government Medical College Srinagar20 enrolled

Overview

Post Traumatic Stress Disorder is a chronic debilitating illness and few treatment options have demonstrated effectiveness. The study will look at the use of electroconvulsive therapy for the treatment of Post Traumatic Stress disorder in patients who have not responded to multiple antidepressants or cognitive behavioral therapy.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Posttraumatic Stress Disorder

Interventions

Electroconvulsive TherapyPROCEDURE

ECT was administered using the MECTA-SR1 apparatus. The current amplitude was 800 mA, pulse width was 1.5 ms, and pulse frequency was 50 Hz. Stimulus duration was increased as required to elicit an adequate seizure, defined as at least 25 s with EEG monitoring. The ECT course was fixed, and comprised 6 treatments administered with bitemporal electrode placement at a twice-weekly frequency

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Diagnosis of PTSD * Treatment resistance to 4 different antidepressants from 3 different classes * Treatment resistance to CBT * Severe PTSD Exclusion Criteria: * Significant substance abuse * Pregnancy * History of Traumatic Brain Injury * Unstable comorbid medical illness * Organic brain syndrome

Locations (1)

Government Hospital for Psychiatric Disease

Srinagar, Jammu and Kashmir, India

Outcomes

Primary Outcomes

Clinician-Administered Posttraumatic Stress Disorder Scale (CAPS) SCORE

Secondary Outcomes

Montgomery-Asberg Depression Rating Scale score

Time frame: baseline, 48 hrs post 3rd, 6th ECT

Data from ClinicalTrials.gov

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