Effects of Transcranial Magnetic Stimulation to the Cerebellum on Cognition

Johns Hopkins University17 enrolled

Overview

Functional neuroimaging studies have shown that the cerebellum is active during cognitive performance. The investigators hypothesize that stimulation of the cerebellum with transcranial magnetic stimulation will produce brief changes in performance of the task, suggesting that cerebellar activation is necessary for normal cognitive function.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

SINGLE

Enrollment

Conditions

Cognitive Performance

Interventions

Cerebellar transcranial magnetic stimulationDEVICE

single pulse TMS or repetitive TMS at 1 Hz frequency

Eligibility

Sex: ALLMin age: 19 YearsMax age: 30 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * 19-30 years of age * Informed consent Exclusion Criteria: * History of seizure or a family history of epilepsy * History of stroke * Presence of metal anywhere in the head except the mouth * Presence of cardiac pacemakers * Presence of cochlear implants * Presence of implanted medication pump * History of heart disease * Presence of intracardiac lines * Increased intracranial pressure, such as after infarctions or trauma * Children, or outside of age range * Pregnancy * Currently taking tricyclic anti-depressants or neuroleptic medication * History of head trauma * History of respiratory disease

Locations (1)

Kennedy Krieger Institute

Baltimore, Maryland, United States

Outcomes

Primary Outcomes

Behavioral performance (accuracy, or rate of conditioned responses)

Time frame: during computerized task performance (2 hours)

Secondary Outcomes

Reaction time

Time frame: during performance of computerized task (2 hours)

Data from ClinicalTrials.gov

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