Acute Effects of Smoking on Airway Dendritic Cells

University of Rostock16 enrolled

Overview

Airway dendritic cells control pulmonary immune responses to inhaled particles. It is the aim of the present study to investigate the acute effects of smoking on the number and surface molecule expression of human airway dendritic cells.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Tobacco Use Disorder

Interventions

SmokingBEHAVIORAL

Active Comparator: Participants smoke 8 cigarettes in 4 hours.

SmokingBEHAVIORAL

Sham Comparator: Participants are not allowed to smoke for 4 hours.

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Active smoking (at least 10 cigarettes per day) * Age \> 18 years Exclusion Criteria: * Any chronic diseases * Any regular medication * Any signs or symptoms of an acute infection

Locations (1)

University of Rostock

Rostock, Germany

Outcomes

Primary Outcomes

Total number of dendritic cells in bronchoalveolar lavage fluid

Time frame: June - September 2008

Secondary Outcomes

Surface molecule expression on dendritic cells in bronchoalveolar lavage fluid

Time frame: June - September 2008

Data from ClinicalTrials.gov

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