Quantifying Airway Inflammation With Radiologic Tests

Inclusion Criteria: * Healthy, man or woman, any race or ethnicity, age 19 - 44 years old * Screening FEV1 and FVC must be \> 80% of predicted. * Screening oxygen saturation by pulse oximetry is \>97% on room air. * Research volunteer must be capable of lying still and supine within the PET scanner for \~2 ½ hours. * Research volunteer must be capable of fasting for 6 hours. Exclusion Criteria: * Pregnancy (confirmed by a qualitative urine hCG pregnancy test) * Lactation. * Actively menstruating at time of randomization * History of tobacco use or has smoked other illicit drugs (marijuana, cocaine) in the past year. * Research volunteer is currently taking any prescription medications. * Research volunteer is at increased risk for radiation exposure (e.g. flight attendants) * Research volunteer is enrolled in another research study of an investigational drug. * Research volunteer has a known allergy to both trimethoprim/sulfamethoxazole and amoxicillin. * Research volunteer has a known allergy to drugs routinely used during bronchoscopy. * Research volunteer has a known allergy to lovastatin or rhAPC * Fasting glucose at time of PET study \> 150 mg/dl. * Exclusion criteria related to use of rhAPC: * Active or history of internal bleeding within the past 3 months * History of hemorrhagic stroke within the past 3 months. * History of intracranial or intraspinal surgery, or severe head trauma, within the past 3 months * History of trauma with an increased risk of life-threatening bleeding within the past 3 months * History of receiving thrombolytic therapy within the past 3 months. * History of receiving oral anticoagulants or glycoprotein IIb/IIIa inhibitors within the past 3 months. * History of using aspirin \> 650 mg/d or other platelet inhibitors within the past 7 days. * Any history of intracranial arteriovenous malformation or aneurysm * Any history of a known bleeding diathesis * Any history of chronic severe hepatic disease * Presence of an epidural catheter * Any history of intracranial neoplasm or mass lesion or evidence of cerebral herniation * Use of heparin during past 7 days * Platelet count \<100,000 x 106/L * Prothrombin time-INR \> 1.5 * SGOT \>47 IU/L, SGPT \> 53 IU/L, or bilirubin \> 1.1 mg/dl * Any other condition in which bleeding constitutes a significant hazard or would be particularly difficult to manage because of its location. * Exclusion criteria related to use of lovastatin: * History of chronic active liver disease or acute liver disease within the past 3 months * SGOT \>47 IU/L, SGPT \> 53 IU/L, or bilirubin \> 1.1 mg/dl.