DESWT-Pilot Study on the Safety of Myocardial Regeneration by Direct Epicardial Shock Wave Therapy in Combination With Coronary Artery Bypass Grafting

Inclusion Criteria: * Male or female patients above 18 years of age undergoing primary coronary artery bypass grafting. * Patients have to present with reduced left ventricular function defined as LVEF \< 50%. * Patients have to present with regional left ventricular wall motion abnormalities. * Patients have to give written informed consent to participate in the study. Exclusion Criteria: * Significant concomitant valve disease(except significant valve disease not detected in preoperative cardiac ultrasound that is detected intra-operatively). * HIV positive patients. * Hepatitis C positive patients. * Patients in cardiogenic shock. * Patients with a contraindication for cardiac MRI. * Present contraindication for transoesophageal echocardiography (TEE). * History of significant ventricular arrhythmias, except arrhythmias associated with MI. * Highly reduced left ventricular function defined as LVEF \<30%. * Present co-morbidity which reduces life expectancy to less than 6 months. * Presence of ventricular thrombus. * Presence of a cardiac tumor. * Pregnancy.