Cardiovascular Impact of Obstructive Sleep Apnea Treatment in Normotensive Patients

University of Sao Paulo36 enrolled

Overview

Recent evidences suggest that obstructive sleep apnea (OSA) can contribute to cardiovascular disease even in the absence of hypertension. However, there are few data regarding the impact of OSA on the preHypertension and Masked Hypertension in apparently normotensive patients with OSA as well as the impact of treatment with continuous positive airway pressure.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Obstructive Sleep Apnea

Interventions

CPAPDEVICE

Control - no treatment

CPAPDEVICE

CPAP: The airway pressure will be determined by an overnight sleep study titration.

Eligibility

Sex: MALEMin age: 30 YearsMax age: 60 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Severe OSA patients Exclusion Criteria: * Smoking * Sustained Hypertension * Heart failure * Diabetes * Renal diseases * Under use of any medication * Under treatment for OSA

Locations (1)

Heart Institute (InCor)

São Paulo, São Paulo, Brazil

Outcomes

Primary Outcomes

Office Blood Pressure

Evaluation of PreHypertension

Secondary Outcomes

24 Hour Ambulatory Blood Pressure Monitoring

Evaluation of Masked Hypertension

Data from ClinicalTrials.gov

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