Efficacy and Safety of Galantamine for Improving Dysfunction in People With Bipolar Disorder

Inclusion Criteria: * DSM-IV diagnosis of Bipolar I disorder or Bipolar II disorder * A baseline Hamilton-D 17 score of less than 10 at screening visit * A baseline Young Mania Rating Scale (YMRS) score of less than 10 at screening visit * No acute episodes of depression or mania for the previous 12 weeks * Score of 17 or higher on the Massachusetts General Hospital (MGH) Cognitive and Physical Functioning Questionnaire * Treated with psychiatric medications, alone or in combination, having only minimal, mild or moderate cognitive burden \[as determined by a score of less than 3.5 on the MGH Cognitive Impact of Psychotropic Medications Scale (CIPMS). * Able to understand English Exclusion Criteria: * DSM-IV diagnosis of Bipolar NOS, Cyclothymia, or Schizoaffective Bipolar type. * Meets DSM-IV criteria for acute manic, depressive, or mixed bipolar episode or had met full criteria for 2 consecutive weeks within the past 12 weeks prior to assessment * Treated with psychiatric medications with large effects on cognition (as determined by a MGH Cognitive Impact of Psychotropic Medications Scale score of 4.0 or above) * Pregnant women or women of child bearing potential who are not using a medically accepted means of contraception (defined as oral contraceptive pill or implant, condom, diaphragm, spermicide, IUD, s/p tubal ligation, partner with vasectomy) * Serious suicide or homicide risk * Unstable medical illness including cardiovascular, hepatic, renal, respiratory, endocrine, neurological, or hematological disease. * History of seizure disorder, brain injury, or any known neurological disease (multiple sclerosis, degenerative disease such as ALS, Parkinson disease and any movement disorders, etc) * The following DSM-IV diagnoses: 1) organic mental disorders; 2) any diagnosis of dementia; 3) substance use disorders, including alcohol, active within the last year; 4) schizophrenia; 5) delusional disorder; 6) psychotic disorders not elsewhere classified; 7) schizoaffective disorder; 8) major depressive disorder; 9) acute bereavement; 10) severe borderline or antisocial personality disorder * Presence of mood congruent or mood incongruent psychotic features * Clinical or laboratory evidence of hypothyroidism * History of multiple adverse drug reactions, allergy to galantamine or other AChEIs * Current use, or use within the last week, of excluded drugs (psychotropic medications and other central nervous system (CNS)-active drugs) * Taken an investigational psychotropic drug within the last year * Had electroconvulsive therapy (ECT) within the 6 months preceding enrollment