The aim of the present Paris Prospective Study III (PPS3) is (1) to assess the determinants of the regulation of heart rate and blood pressure variations and carotid properties (under different physiologic stimulations) and (2) to evaluate the respective contribution of heart rate, blood pressure variations and carotid properties to cardiovascular morbidity and mortality including sudden death during 10 years at least in healthy considered subjects.
Overall, 10 157 men and women have been recruited during May 2008 and June 2012 for an extensive clinical examination including a 2h holter electrocardiography (ECG), a carotid doppler echo tracking, a step test, as well as blood and DNA collections. Since then, the cardiovascular morbidity and mortality of the participants is being followed up for 10 years at least and will continue up to 2032.
Study Type
OBSERVATIONAL
Enrollment
10,157
cardiac rhythm recorded during health check up, vascular aging parameters and baroreflex sensitivity recorded during carotid echotracking of the right common carotid artery , step test during 2 minutes
Investigations Pré cliniques et Preventives de Paris
Paris, France
cardiovascular disease (CVD)
incident coronary heart disease (CHD), stroke, sudden death, mortality
Time frame: through study completion, an average of 24 years
heart rate parameters and baroreflex sensitivity
as measured on the Spider Flash ECG and the carotid echotracking
Time frame: 4 Years
other CVD outcomes
heart failure, arterial aneurysms, venous thromboembolism (VTE), pulmonary embolism, arrhythmic events (atrial fibrillation, flutter)
Time frame: through study completion, an average of 24 years
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